Furosemide-Albumin Complex Unreliable Partner in Therapy of Hypoalbuminemic Anuric Patients
نویسندگان
چکیده
منابع مشابه
Effects of albumin/furosemide mixtures on responses to furosemide in hypoalbuminemic patients.
Hypoalbuminemic patients often have sufficient fluid accumulation to mandate diuretic therapy but are often resistant to diuresis. Studies have suggested that hypoalbuminemia itself impairs delivery of effective amounts of diuretic agent into the urine, the site of action. Therefore, administration of mixtures of albumin and loop diuretics may enhance responses. Thirteen patients with biopsy-pr...
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Protein binding significantly influences pharmacokinetic properties of drug distribution. Albumin accounts for approximately 60% of the total plasma protein by mass, thereby making it the major protein in the body. Hypoalbuminemia, a type of hypoproteinemia, is a condition of abnormally low blood albumin levels. Hypoaluminemia causes pharmacokinetic issues in regards to dosing a patient's medic...
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BACKGROUND Chronic kidney disease (CKD) with edema is a common clinical problem resulting from defects in water and solute excretion. Furosemide is the drug of choice for treatment. In theory, good perfusion and albumin are required for the furosemide to be secreted at the tubular lumen. Thus, in the situation of low glomerular filtration rate (GFR) and hypoalbuminemia, the efficacy of furosemi...
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OBJECTIVE To test the hypothesis that administration of albumin to correct hypoalbuminemia might have beneficial effects on organ function in a mixed population of critically ill patients. DESIGN : Prospective, controlled, randomized study. SETTING Thirty-one-bed, mixed medicosurgical department of intensive care. PATIENTS All adult patients with a serum albumin concentration < or =30 g/L...
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Background: Administration of albumin for burn patients and its effects on mortality and morbidity has been debated for along time. The aim of this study was to evaluate the effects of albumin administration on wound healing, length of hospital stay, weight change, and mortality of burn patients. Methods: Two matched groups of patients from Shiraz Burn Care Center were randomly selected. The pa...
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ژورنال
عنوان ژورنال: Nephron
سال: 1997
ISSN: 1423-0186,0028-2766
DOI: 10.1159/000190332